Which COVID Vaccine Booster is Best? Pfizer vs. Moderna vs. J. Johnson (Update 133)

Roger Seheult, MD of MedCram explains COVID 19 booster data on Moderna, Pfizer-BioNTech, and Johnson & Johnson and the efficacy of each coronavirus booster vs. full vaccination.

Roger Seheult, MD is the co-founder and lead professor at
He is Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine and an Associate Professor at the University of California, Riverside School of Medicine.

(This video was recorded on October 27, 2021)


Pfizer And BioNTech Announce Phase 3 Trial Data Showing High Efficacy Of A Of Their COVID-19 Vaccine (Pfizer) |

Heterologous SARS-CoV-2 Booster Vaccinations – Preliminary Report (medRxiv) |

All coronavirus updates are at MedCram.com (including more discussion on the COVID delta variant, vaccine passport, and more).


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Video Produced by Kyle Allred



MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.

#COVID19 #SARSCoV2 #Coronavirus

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Tiêu đề video: Which Booster is Best? Pfizer vs. Moderna vs. J. Johnson (Update 133)

Độ dài: 00:16:01, Ngày đăng: 2021-10-28 02:51:18

Tác giả: MedCram – Medical Lectures Explained CLEARLY

Link gốc: https://www.youtube.com/watch?v=YhMlZczq4Ns


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  1. This is all very interesting but here in the UK we don’t have a choice!

  2. I want to see the results of people who had COVID, then got fully vaccinated, then got boosted and compare to non-boosted.

  3. How about the AstraZenica and Sinovac?

  4. Happy to have have taken the Pfizer boost after getting the J&J. Felt a little hot the first night and a bit tired the next day (but went hiking anyway), and felt great afterwards.

  5. Please talk about aspirating or drawing back when injecting the vaccine. If it’s injected into the bloodstream it increases your chance of myopericarditis. The deltoid is a muscle that needs a blood supply and therefore has blood vessels. Aspirate to vaccinate!

  6. Excellent. Any information with astra zeneca ?

  7. Answer: The one with the current spike.

  8. This is good information and I appreciate the work. In my case you are recommending Moderna but this is with the full dose. Is there anyway of knowing how this data sill change with the half dose? ( I had Moderna originally) Otherwise it might be better for me to get Pfizer.

  9. Interesting how AstraZeneca was not even considered.

  10. Thank you for this. Looking forward to followup with new info in the future….!

  11. How would you extrapolate Moderna boost as a half dose?

  12. Amazing how you take a complicated subject and make it sooo easy to understand … wish you were my chem. Bio .anatomy prof in college …

  13. My question is the virus is changing and the change is in the spike proteins, this is why Delta was so bad as it was different from Alpha. Delta seems to run its course and now it’s other variants coming our way. So why get Alpha boosters for a virus that is no longer around.

  14. Steve Pottschmidt

    I just received my flu vaccine. How long do I need to wait to get a COVID booster?

  15. still trying to decide to stick with pfizer or try the moderna and mix it up. anybody gone this route yet? i wish this data had the half dose moderna. oh well.

  16. Thank you, Meccram !!!
    ** Could you Please make a video on the myocarditis & related risks with Moderna, and how 3 Nordic countries ( Sweden, Norway, and Finland) have suspended Moderna for people under 30 ( in Sweden for men AND women that age.)**
    How safe is Moderna for women in their 40's and 50's? ( Concerned re: myocarditis, blood clots, etc.)….but I'd LIKE to get a Moderna booster, if safe enough ( I got J& J initially.) THANKS SO MUCH !!!

  17. Best episode ever…
    The question still remains regarding the effect of HALF dose Moderna… could you please clarify if you have any data available for half dose booster …
    Looks like as a Pfizer recipient, another dose of Pfizer is the best for me as Moderna is ''just half dose'' – wrong assumption?

  18. If this is A worldwide pandemic why whould you have
    multiple Companys
    with different vaccines instead of compiling data and going with what really has Best efficacy rates.

  19. Thanks Dr Seheult.  I think compliance would be a whole lot better if we implemented a baseline quantitative antibody level test.  If we could determine what the minimum immunity level would be based on scientific studies and used that as the "magic number" by which to recommend vaccination. It's a reasonable and logical approach that we already use for other infectious diseases, but somehow have been ignoring with Covid19.  Any comments on this idea??

  20. Dr Seheult if you already have anti-bodys present
    from previous infection why whould you get
    the Vaccine.

  21. Good info. Thank you. I took a 3rd dose Moderna in Aug as I'm immune compromised, and my paper says .50 dosage .Does not say micro grams..just .50 .I'm wondering if I was given half dose?

  22. I got Moderna shots in Jan/Feb 2020, and phizer booster in Oct. No side effects other than light pain in arm for 3 days.
    Had slight fever and fatigue 1 day after second Moderna shot.

  23. and if your Vaccine was anther brand? Such as AstraZeneca ?

  24. As usual very good analysis and breakdown. Thank you. I live a country where we use Astra-Zeneca/Oxford. Is there any date about mixing with other vaccine as booster? Or why AZ not included in the study? Thank you.

  25. I believe moderna booster dose is .25 ml not .50 ml

  26. Since there is no statistical difference between vaccinated and unvaccinated populations contracting the cv-bioW, why are we getting vaccinated?

  27. The question everyone is asking is "if you get it after you are vaccinated does it negate the need for a booster jab?"

  28. Thank you so much for this great information, I am vaccinated with moderna and hope to get my booster shot with it also,My 13 yr old granddaughter got Pfizer but I want her booster shot to be moderna,I had my eye on moderna for a while before it was approved and I'm so happy it's working well, but I still wear a mask and don't leave home unless I really have to I've got COPD and think I still won't fair well with C-19 God bless you for taking time to get this out I feel better knowing all I can, and I'm pretty sure we are in for another round of the delta offspring after Thanksgiving so buckle up everyone and try to be safe

  29. Are boosters necessary? This is all really confusing 😕

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